By leveraging artificial intelligence and machine learning techniques, researchers will employ a new computational fluid dynamic (CFD) model of the 3D-ICE process to develop advanced biomanufacturing approaches for 3D bioprinting organ-on-a-chip systems. They will also examine whether closed loop control for 3D-ICE biomanufacturing using computer vision and machine learning-based feedback could enable the biofabrication of branching collagen scaffolds with tunable dimensions to engineer human lung mimetic systems.
