Carnegie Mellon researchers are developing artificial and tissue based approaches to create more biocompatible cardiac support. Artificial approaches include a muscle-driven, extra-cardiac ventricular assist device for long-term cardiac support. Our tissue-based approach integrates developmental biology, stem cell science, materials science and engineering, and additive manufacturing to print replacement cardiac tissues.
The heart, unlike skin, cannot heal itself once it becomes damaged. Given enough damage, a patient may require a heart transplant to survive, but currently the number of people who need a transplant largely outnumbers the amount of hearts available. Carnegie Mellon researchers are developing techniques to use 3-D printers to "bioprint" heart tissue that could someday replace damaged heart tissue, alleviating the necessity of a transplant altogether.
- 3D bioprinting of collagen to rebuild components of the human heart
- Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels
- 3D bioprinting from the micrometer to millimeter length scales: Size does matter
- 3D Printing PDMS Elastomer in a Hydrophilic Support Bath via Freeform Reversible Embedding
Artificial heart assist device with a muscle-driven energy source
Carnegie Mellon researchers are working to solve two of the biggest problems with long-term use of cardiac assist devices: risk of infection from an externally connected device and blood clots caused by blood-contacting surfaces. They are creating a novel device that is completely implantable and does not require any connection to an external power source. Instead, the implantable device has its own internal power source that converts muscle contractions into hydraulic energy. And because the device acts to compress the heart from the outside and does not contact the bloodstream, patients would avoid complications due to blood clots or bleeding caused by anticoagulation medication.
- A Muscle-Powered Counterpulsation Device for Tether-Free Cardiac Support: Form and Function
- Potential Mechanisms for Muscle-Powered Cardiac Support
- Design Improvements and In Vitro Testing of an Implantable Muscle Energy Converter for Powering Pulsatile Cardiac Assist Devices
- Improved Mechanism for Capturing Muscle Power for Circulatory Support