Biomedical Engineering

Bone bioengineering: Microstructure, mechanics, mechanobiology, and beyond

October 11, 2018

10:30 a.m. - 11:30 a.m.

Baker Hall, Room 136A

Edward Guo, Ph.D.
Stanley Dicker Professor and Chair
Department of Biomedical Engineering
Columbia University in the City of New York

Abstract

The Bone Bioengineering Laboratory is developing innovative technology in microstructural assessments, biomechanical modeling, and multiscale and mechanobiological approaches in skeletal research. Bone bioengineering has both basic science and clinical significance in many medical fields, such as osteoporosis, osteoarthritis, or intervertebral disc degenerations. Guo will highlight the lab's development of a three-dimensional imaging analysis and modeling technique for trabecular bone microstructure, its applications in basic scientific research of bone mechanics, and clinical applications in osteoporosis and osteoarthritis. In parallel to these developments, he will also discuss multiscale mechanobiological approaches in understanding the mechanisms of how bone senses and responds to mechanical loading and showcase some recent findings in new mechanotransduction phenomena. Finally, Guo will discuss bone microstructural phenotypes in difference races and their implications in genetic and precision medicine, anthropology, evolution, and mechanobiology of the skeletons.

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